Diseases Treated With Stem Cells And Other Potential Applications

BLOOD CANCERS

Leukaemia

  • Acute Biphenotypic Leukemia*
  • Acute Lymphoblastic Leukaemia*
  • Acute Myelogenous Leukaemia*
  • Acute Undifferentiated Leukemia*
  • Chronic Myelogenous Leukaemia*
  • Chronic Lymphocytic Leukemia*
  • Juvenile Myelomonocytic Leukemia*
  • Juvenile Chronic Myelogenou Leukemia (JCML)

Myeloproliferative Neoplasms

  • Acute Myelofibrosis
  • Agnogenic Myeloid Metaplasia
  • Essential Thrombocythemia
  • Polycythemia Vera
  • Systemic Mastocytosis*

Myelodysplastic Syndromes

  • Refractory Anemia*
  • Refractory Anemia with Excess Blasts*
  • Refractory Anemia with Excess Blasts in Transformation*
  • Refractory Anemia with Ringed Sideroblasts (Sideroblastic anemia)*
  • Chronic Myelomonocytic Leukemia*

Other Blood Cancers

  • Multiple Myeloma
  • Plasma Cell Leukaemia
  • Waldenstrom's Macroglobulinemia
  • Histiocytic Neoplasms

SOLID TUMOR

  • Hodgkin's Lymphoma*
  • Langerhans’ Cell Histiocytosis*
  • Neuroblastoma*
  • Non-Hodgkin's Lymphoma*
  • Retinoblastoma
  • Medulloblastoma
  • Wilms Tumor


NON-MALIGNANT BLOOD DISORDERS

Anaemias (Deficiencies or Malformations of Red Cells)

  • Aplastic Anaemia*
  • Congenital Dyserythropoietic Anaemia
  • Fanconi’s Anaemia*
  • Paroxysmal Nocturnal Hemoglobinuria

Hereditary Bone Marrow Failure Syndromes

  • Diamond-Blackfan Syndrome*
  • Dyskeratosis Congenita*
  • Pearson's Syndrome
  • Shwachman-Diamond Syndrome*

Inherited Red Cell Abnormalities

  • Pure Red Cell Aplasia
  • Sickle Cell Anaemia*
  • Beta Thalassemia Major/Cooley's Anaemia**

Inherited Platelet Abnormalities

  • Congenital Amegakaryocytosis Thrombocytopenia
  • Glanzmann's Thrombasthenia*


IMMUNODEFICIENCY DISORDERS

Severe Combined Immune Deficiency (SCID)

  • Bare Lymphocyte Syndrome*
  • Omenn Syndrome*
  • Reticular Dysgenesis
  • Neutrophil Actin Deficiency*
  • SCID with Adenosine Deaminase Deficiency (ADA-SCID)*
  • SCID which is X-linked*
  • SCID with absence of T & B Cells*
  • SCID with absence of T Cells, Normal B Cells*

Neutropenias

  • Kostmann Syndrome (Infantile Genetic Agranulocytosis)*
  • Myelokathexis*

Phagocyte Disorders

  • Chediak-Higashi Syndrome*
  • Chronic Granulomatous Disease*

Inherited Disorders of the Immune System & Other Organs

  • Cartilage-Hair Hypoplasia
  • Gunther’s Disease (Congenital Erythropoietic Protoporphyria)*

Other Inherited Immune System Disorders

  • Common Variable Immunodeficiency*
  • DiGeorge Syndrome*
  • Evans Syndrome*
  • Hemophagocytic Lymphohistiocytosis
  • IKK Gamma Deficiency (NEMO Deficiency)*
  • IPEX Syndrome*
  • Leukocyte Adhesion Deficiency*
  • Wiskott-Aldrich Syndrome*
  • X-linked Lymphoproliferative Disease (Duncan’s syndrome)*
  • X-linked Hyper IgM Syndrome
  • Ataxia-Telangiectasia


METABOLIC DISORDERS

Leukodystrophy Disorders

  • Adrenoleukodystrophy*
  • Krabbe Disease (Globoid Cell Leukodystrophy)*
  • Metachromatic leukodystrophy*
  • Pelizaeus-Merzbacher Disease*

Lysosomal Storage Diseases

  • Alpha-Mannosidosis*
  • Gaucher’s Disease
  • Niemann-Pick Disease
  • Sandhoff Disease
  • Wolman Disease*

Mucopolysaccharidosis (MPS) Storage Diseases

  • Hunter Syndrome*
  • Hurler Syndrome*
  • Maroteaux-Lamy Syndrome*
  • Mucolipidosis II (I-cell Disease)*
  • Sanfilippo Syndrome*
  • Morquio Syndrome
  • Scheie Syndrome*
  • Sly Syndrome (beta-glucuronidase deficiency)

Other Metabolic Disorders

  • Hermansky-Pudlak Syndrome
  • Lesch–Nyhan Syndrome*
  • Osteopetrosis*


Clinical Trials

  • Alzheimer’s Disease*
  • Amyotrophic Lateral Sclerosis
  • Autism*
  • Brain Tumour
  • Cardiomyopathy
  • Cartilage repair
  • Cerebral palsy*
  • Cleft Palate Repair (Alveolar)
  • Compartment Syndrome(Battlefield Trauma)
  • Critical Limb Ischemia
  • Crohn's disease
  • Diabetes Type 1*
  • Epidermolysis Bullosa*
  • Ewing Sarcoma
  • Graft-versus-Host Disease (GvHD)
  • Hearing Loss (acquired sensorineural)*
  • HIV*
  • Huntington’s Disease
  • Hypoplastic Left Heart Syndrome*
  • Hypoxic Ischemic Encephalopathy*
  • Ischemic Heart Disease
  • Ischemic Stroke
  • Kidney plus stem cell transplant
  • Liver cirrhosis*
  • Lupus
  • Multiple Sclerosis
  • Myocardial Infarction
  • Open cardiac surgery for congenital heart diseases
  • Ovarian Cancer (Link to clinical trials)
  • Parkinson’s Disease
  • Rhabdomyosarcoma
  • Rheumatoid Arthritis
  • Scleroderma
  • Spinal cord injury*
  • Testicular Tumour
  • Tissue Engineered Vascular Grafts for cardiac defects
  • Traumatic Brain Injury
  • Adrenoleukodystrophy
  • Chronic Granulomatous Disease (X-linked)
  • Fanconi Anemia
  • Metachromatic Leukodystrophy
  • Severe Combined Immunodeficiency X-linked (SCID-X1)
  • Severe Combined Immunodeficiency X-linked (ADA-SCID)
  • Sickle Cell
  • Thalassemia
  • Wiskott-Aldrich Syndrome
  • Bronchopulmonary Dysplasia (BPD)
  • Lysosomal Storage Diseases

The above is a list of some diseases that have been treated with cord blood and other sources of similar stem cells (haematopoietic stem cells), such as bone marrow and peripheral blood. Banking cord blood does not guarantee that the cells will provide a cure or be applicable in every situation. The use of stem cells will ultimately be determined by the treating physician.

* Treated with cord blood.

Reference:

DCR 920 QR 8.1-8-11 b

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