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Penggunaan Potensial Sel Punca Membran Tali Pusat

Mesenchymal stem cells (MSCs)

Perbaikan jaringan

  • Cardiovascular diseases (e.g. cardiac muscle repair)
  • Orthopaedic applications (osteoarthritis, cartilage and tendon repair)
  • Pulmonary fibrosis1
  • Stroke2,3
  • COVID-1922
  • Neurodegenerative disease:
    • Alzheimer's disease
    • Parkinson's disease
  • Developmental disorder:
    • Autism Spectrum Disorder (ASD)4,5,6
    • Cerebral palsy and paralysis
    • Global Developmental Delay
  • Spinal cord injury7
  • Liver regeneration from liver failure8,9,10

HSC engraftment support11

  • Shorten time of engraftment
  • Reduce immune system complications

Immune modulation or reconstitution12

  • COVID-1922
  • Prevention and treatment of Graft vs Host Disease (GvHD)13
  • Diabetes type 1 & 214
  • HIV15
  • Crohn's disease16

Cord lining epithelial cells (CLECs)

Perbaikan jaringan lunak dan luka

  • Disorder of upper respiratory system
  • e.g. repair and regeneration of bronchial epithelium for smokers
  • Surface ulcer (diabetic)
  • Various types of burns17
  • Tissue trauma
  • Skin wounds
  • Epidermal reconstitution18

Organ lining regeneration

  • Liver lining
  • Pancreatic lining
  • Gastrointestinal lining

Mata19

  • Corneal dermoid
  • Corneal scars and opacities
  • Corneal ulcers
  • Dry eye syndromes
  • Eye injury (e.g. chemical burn)
  • Limbal deficiency
  • Limbal corneal insufficiency syndrome
  • Macular degenerative diseases:
    • Age related myopia
    • Stargardt's macular dystrophy
  • Ocular surface disease
  • Pterygium
  • Ocular damage due to Stevens Johnson Syndrome

Hingga September 2020, ada lebih dari 1.276 uji klinis yang dilakukan di seluruh dunia untuk mencari tahu kegunaan sel punca membran tali pusat. 20 Sejauh ini, hasil yang menggembirakan telah dipublikasikan. Telah terbukti bahwa perawatan sel punca aman dan mampu memperbaiki kerusakan yang disebabkan oleh stroke dan penyakit jantung. HSCs juga telah digunakan dengan MSCs sebagai terapi ganda untuk mempromosikan pengikatan HSCs yang lebih cepat dan untuk mengurangi komplikasi sistem kekebalan tubuh.21

Meskipun ada bukti bahwa epithelial cells (ECs) dapat diturunkan dari MSC, ini tidak membuat cord lining epithelial cells (CLECs) menjadi kurang penting.

CLECs adalah sel punca yang berasal dari membran tali pusat. Mereka dapat berubah menjadi semua jenis EC sesuai permintaan, seperti kulit, kornea, lapisan usus, dan sebagainya. Di sisi lain, EC telah mencapai diferensiasi terminal dan tidak dapat berubah menjadi tipe EC yang berbeda.

Oleh karena itu, kami menyarankan Anda untuk menyimpan MSC dan CLEC karena keduanya tidak dapat menggantikan satu sama lain.

References

1 Chuang HM, Shih TE, Lu KY, et al. Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis: Improvement with Target Combination. Cell Transplant. 2018;27(11): 15811587. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299195/
2 Wang F, Tang H, Zhu J, Zhang JH. Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018;27(12):1825-1834 https://www.ncbi.nlm.nih.gov/pubmed/30251564
3 Xue P, Wang M, Yan G. Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke in asia: a meta-analysis of controlled trials. Ther Clin Risk Manag. 2018; 14: 909928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957058/
4 Shane, et al. Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? Autism Open Access. 2015; 5(3) https://www.longdom.org/open-access/do-the-stem-cells-really-work-with-autism-spectrum-disorders-associatedwith-neuroimmune-interaction-2165-7890-1000151.pdf
5 Liu Q, Chen MX, Sun L, et al. Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders. World J Stem Cells. 2019; 11(2): 5572. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397804/
6 Siniscalco D, Kannan S, Semprn-Hern¡ndez N, et al. Stem cell therapy in autism: recent insights. Stem Cells Cloning. 2018; 11: 5567. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204871/
7 Xu P, Yang X. The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review. Cell Transplant. 2019; 28(1): 3646. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322141/
8 Alfaifi M, Eom YW, Newsome PN, et al. Mesenchymal stromal cell therapy for liver diseases. J Hepatol. 2018;68(6):1272-1285. https://www.ncbi.nlm.nih.gov/pubmed/29425678
9 Maria P. de Miguel, I. Prieto, et al. Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials. Stem Cells International. 2019:3945672 https://www.hindawi.com/journals/sci/2019/3945672/
10 Wang YH, Wu DB, Chen B, et al. Progress in mesenchymal stem cell–based therapy for acute liver failure. Stem Cell Research & Therapy. 2018;9(1):227 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109312/
11 Crippa S, Bernardo ME. Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation. HemaSphere. 2018;2:6. https://journals.lww.com/hemasphere/Fulltext/2018/12000/Mesenchymal_Stromal_Cells__Role_in_the_BM_Niche.5.aspx
12 Damien P, Allan DS. Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood-Derived Cells. Biol Blood Marrow Transplant. 2015;21(9):1545-54. https://www.bbmt.org/article/S1083-8791(15)00379-1/pdf
13 Zhao L, Chen S, Yang P, et al. The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease. Stem Cell Research & Therapy. 2019; 10: 182 https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1287-9
14 Clinical trials .Gov Website. Last accessed September 25, 2019 https://clinicaltrials.gov/ct2/results?cond=diabetes+mesenchymal+stem+cells&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=&rslt=
15 Zhang Z, Fu J, Xu X, et al. Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients. AIDS. 2013; 27(8): 1283,1293 https://www.ncbi.nlm.nih.gov/pubmed/23925377
16 ClinicalTrials.org registry NCT01090817, NCT01157650, NCT01659762, NCT00294112, NCT00482092, NCT03901235, NCT03449069, NCT00543374, NCT03220243, NCT02445547. Last accessed September 25, 2019
17 ClinicalTrials.org registry NCT02904941, NCT03162367, NCT00856934, NCT00832156,NCT02145130, NCT03227146, NCT03229564, NCT02948023, NCT04030754, NCT03754218, NCT01655407, NCT02947737, NCT02765737, NCT00548314, NCT02325843, NCT03048188, NCT03913481, NCT02779205, NCT03791710, NCT02577861, NCT03686449. Last accessed September 25, 2019
18 Huang L, Wong YP, Gu H, et al. Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011;13:14555. https://www.ncbi.nlm.nih.gov/pubmed/20735166
19 ClinicalTrials.org registry NCT00459290, NCT00841581, NCT03916679,NCT03687632,NCT03608293, NCT02586883, NCT01722656, NCT00003704, NCT00667641, NCT02573324, NCT01166763, NCT01376349, NCT00999531, NCT00335491, NCT03519178, NCT00291135, NCT01635231. Last accessed September 25, 2019
20 Clinical Trials website. https://clinicaltrials.gov/ct2/results?term=mesenchymal&age_v=&gndr=&type=Intr& . Last accessed September 8 2020.
21 Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.
22Afarid M, Sanie-Jahromi F. Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and Vaccination. Stem Cells International 2021. 2021;0705:1-12

Penelitian di seluruh dunia tentang penyakit yang diobati dengan MSC oleh berbagai universitas dan lembaga penelitian:
PENYAKITNAMA UNIVERISTA/LEMBAGA PENELITIAN
Acute Graft vs Host DiseaseUniversity of Kansas Medical Center, Kansas City, United States1
Alzheimer's diseaseSamsung Medical Center, Seoul, Korea2
Cerebral palsyDuke University Medical Center, North Carolina, United States3
Chronic ischemic cardiomyopathyNanjing University Medical School, Nanjing, China4
Diabetes Type 1University Medical School, Nanjing, China5
Van Hanh General Hospital, Ho Chi Minh, Vietnam6
Diabetes Type 2Van Hanh General Hospital, Ho Chi Minh, Vietnam7
Left ventricular dysfunctionShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China8
Liver failureXijing Hospital of Digestive Diseases, Shaanxi, China9
OsteoarthritisUniversitas Indonesia, Jakarta, Indonesia10
Parkinson's diseaseUniversity of Jordan, Amman, Jordan11
Rheumatoid arthritisStem Cell Institue, Panama City, Panama12
Xijing Hospital, Shaanxi, China13
Chonnam National University Hospital,
Gangdong Kyung Hee University Hospital,
Konkuk University Medical Center,
Kyung Hee University Hospital,
Seoul National University Boramae,
Seoul National University Hospital, Seoul, Korea14
Spinal cord injuryHospital de Neurorehabilitació, Barcelona, Spain15
Knee osteoarthritisLiaocheng City People's Hospital, Shandong, China16
Systemic lupus erythematosusMedical University of South Carolina, Charleston, United States17

References

1 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03158896. Last accessed September 25, 2019.
2 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT02054208. Last accessed September 25, 2019.
3 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03473301. Last accessed September 25, 2019.
4 Clinical Trials website. https://ClinicalTrials.gov/show/NCT02635464. Last accessed September 25, 2019.
5 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT02763423. Last accessed September 25, 2019.
6 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03484741. Last accessed September 25, 2019.
7 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03943940. Last accessed September 25, 2019.
8 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03902067. Last accessed September 25, 2019.
9 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03668171. Last accessed September 25, 2019.
10 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03800810. Last accessed September 25, 2019.
11 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03684122. Last accessed September 25, 2019.
12 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT01985464. Last accessed September 25, 2019.
13 Clinical Trials website. https://clinicaltrials.gov/ct2/show/NCT03798028. Last accessed September 25, 2019.
14 Clinical Trials website. https://ClinicalTrials.gov/show/NCT03618784. Last accessed September 25, 2019.
15 Clinical Trials website. https://clinicaltrials.gov/show/NCT03003364. Last accessed September 25, 2019.
16 Clinical Trials website. https://clinicaltrials.gov/show/NCT03166865. Last accessed September 25, 2019.
17 Clinical Trials website. https://clinicaltrials.gov/show/NCT02633163. Last accessed September 25, 2019.

Penelitian di seluruh dunia tentang penyakit yang diobati dengan epithelial cells (ECs) oleh berbagai universitas dan lembaga penelitian:
PENYAKITNAMA UNIVERSITAS/LEMBAGA PENELITIAN
Skin woundSingapore General Hospital Burn Centre
Ocular surface disordersSingapore Eye Research Institute
Kyoto Prefectural University of Medicine, Japan
Persistent epithelial defectNational Eye Institute, Hanoi, Vietnam

DCR No. 4525, Version C, January 2022.