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Cord Lining
Cord Lining

Potential Therapeutic Application

Source Umbilical Cord Lining1
Type of Stem Cells Mesenchymal Stem Cells (MSCs) Cord Lining Epitheliel Cells (CLEPSCs)

Potential Treatment for

Tissue repair

  • Cardiovascular Diseases (e.g. Cardiac muscle repair)
  • Orthopaedic Applications (Osteoarthritis, cartilage and tendon repair)
  • Pulmonary Fibrosis
  • Stroke
  • Spinal Cord Injury
  • Liver Regeneration From Liver Failure

Neurodegenerative Disease

  • Alzheimer's Disease
  • Parkinson's Disease

Developmental Disorder

  • Autism Spectrum Disorder (ASD)
  • Global Developmental Delay

HSCs Engraftment Support

  • Shorten Time of Engraftment
  • Reduce Immune System Complications

Immune Modulation

  • HIV
  • Diabetes: Type 1 and 2
  • Prevention And Treatment Of Graft Versus Host Disease (GvHD)
  • Crohn’s Disease

Wound/ Soft Tissue Rep

  • Disorder of Upper Respiratory Systemair (eg: Repair And Regeneration Of Bronchial Epithelium For Smokers)
  • Surface Ulcer (Diabetic)
  • Various Types Of Burn
  • Tissue Trauma
  • Skin Wounds
  • Epidermal Reconstitution

Organ Lining Regeneration

  • Liver Lining
  • Pancreatic Lining
  • Gastrointestinal Lining

Eye Conditions

  • Corneal Ulcers & Other Corneal Related Indicators
  • Dry Eye Syndromes
  • Eye Injuries
  • Limbal Deficiency
  • Macular Degenerative Diseases
  • Age related myopia
  • Ocular Surface Disease
  • Pterygium

Today, more than 12762(as of September 2020) clinical trials are on-going worldwide to uncover the potential applications of umbilical cord lining stem cells. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications.

Although there is evidence that MSCs can be changed to certain types of Epithelial cells, the cells cannot be changed into Cord Lining Epithelial Stem Cells (CLEpSCs). The difference between Cord Lining Epithelial Stem Cells and Epithelial cells is that Cord Lining Epithelial Stem Cells can differentiate into all different epithelial cell types such as skin, cornea, lining of the gut, etc. on demand. Whereas, (non-stem) Epithelial cells have already reached terminal differentiation so the cells cannot be further changed into different Epithelial cell types when needed. Thus, MSCs and CLEpSCs cannot be replaced by each other.

1 For the full list of potential applications and references, please refer to
2Clinical Trials website. . Last accessed September 8 2020.

DCR No. 1850, January 2020