Potential Therapeutic Application
Source | Umbilical Cord Lining1 | |
---|---|---|
Type of Stem Cells | Mesenchymal Stem Cells (MSCs) | Cord Lining Epitheliel Cells (CLEPSCs) |
Potential Treatment for |
Tissue repair
Neurodegenerative Disease
Developmental Disorder
HSCs Engraftment Support
Immune Modulation
|
Wound/ Soft Tissue Rep
Organ Lining Regeneration
Eye Conditions
|
Today, more than 12762(as of September 2020) clinical trials are on-going worldwide to uncover the potential applications of umbilical cord lining stem cells. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications.
Although there is evidence that MSCs can be changed to certain types of Epithelial cells, the cells cannot be changed into Cord Lining Epithelial Stem Cells (CLEpSCs). The difference between Cord Lining Epithelial Stem Cells and Epithelial cells is that Cord Lining Epithelial Stem Cells can differentiate into all different epithelial cell types such as skin, cornea, lining of the gut, etc. on demand. Whereas, (non-stem) Epithelial cells have already reached terminal differentiation so the cells cannot be further changed into different Epithelial cell types when needed. Thus, MSCs and CLEpSCs cannot be replaced by each other.
1 For the full list of potential applications and references, please refer to https://www.cordlifetech.com/potential-applications
2Clinical Trials website. https://clinicaltrials.gov/ct2/results?term=mesenchymal&age_v=&gndr=&type=Intr& . Last accessed September 8 2020.
DCR No. 1850, January 2020
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